Prior Positions
Assistant Professor of Physiology: University of Illinois at Chicago, Chicago, IL   1991-1997
Senior Scientist I: Geo-Centers, Inc. under contract to Naval Medical Research Institute, Bethesda, MD.  1989-1991
Assistant Professor, Department of Surgery, Loyola University Medical Center, Maywood, IL   1988-1989
Instructor, Barat College, Lake Forest, IL  1987-1989
Visiting Professor, Gama Filho University, Rio de Janeiro, R.J., Brasil   1985-1986
High School Teacher   (basic and advanced physics)  Alleman High School, Rock Island, IL  1979-1981

Membership in Professional Organizations
American Physiological Society (Full)
American Heart Association
American Diabetes Association (Professional)
International Society for Heart Research (Full)
Shock Society 
Society for Critical Care Medicine (Full)

Research Interests
1.  Role of adenosine and adenosine-associated enzyme pathways in physiological and pathophysiological conditions, including circulatory shock, sepsis, and myocardial ischemia.
2.  Role of adenosine in regulation of myocardial cytokines and contractile function.
3. Hemodynamic waveform reduction analyses in physiological and pathophysiological conditions

Contact
Voice:  (312) 996-7622
Fax:      (312) 996-1414
E-mail: wrlaw@uic.edu

LAW, W.R., Valli, V.E., and Conlon, B.A.  Therapeutic Potential for Transient Inhibition of Adenosine Deaminase in Systemic Inflammatory Response Syndrome. Critical Care Medicine May, 2003.

Cohen, E.S,  LAW, W.R., Easington, C.R., Cruz, K.Q., Nardulli, B.A., Balk, R.A., Parrillo, J.E., and Hollenberg, S.M. Adenosine Deaminase Inhibition Attenuates Microvascular Dysfunction and Improves Survival in Sepsis.  Am. J. Resp. Crit. Care Med. (In Press), 2002.

Adanin, S.,Yalovetskiy, I.V., Narduli, B.A., Sam, A.D., II,  Jonjev, Z.S. and LAW, W.R.   Inhibiting Adenosine Deaminase Modulates the Systemic Inflammatory Response Syndrome in Endotoxemia and Sepsis, American Journal of Physiology 282: R1324-R1332, 2002.

Sam, A.D., II, Sharma, A.C., Rice, A.N., Ferguson, J.L., and LAW, W.R.  Interdependence of Adenosine and Nitric Oxide in Hepato-Splanchnic Circulation during Sepsis. J. Surg. Res. 94:61-67, 2000.

Sam, A.D., II, Sharma, A.C., Rice, A.N., Ferguson, J.L., and LAW, W.R. Adenosine and Nitric Oxide Regulate Regional Vascular Resistance vi Interdependent and Independent Mechanisms during Sepsis. Crit. Care Med.   28:1931-1939, 2000.

Motew, S.J., Sam, A.D., II, Mourelatos, M.G., Sharma, A.C., Alden, K.J., Ferguson, J.L., and LAW, W.R. Adenosine Receptor Antagonism Affects Regional Resting Vascular Resistance during Rat Peritoneal Sepsis. J. Surg. Res. 80:326-332, 1998. 

Fogelson, B.G., Nawas, S.I., and LAW, W.R. Mechanisms of Myocardial Protection in Adenosine-Supplemented Cardioplegia: Myofilament and Metabolic Responses. J. Thorac. Cardiovasc. Surg. 119: 601-609,2000.

Nawas, S.I., Schwertz, D.W., Beck, J.M., Fogelson, B.G.,and LAW, W.R. Mechanisms of Myocardial Protection in Adenosine-Supplemented Cardioplegia: Differential Response of Calcium Independent PKC Isozymes J. Surg. Res. 89:163-168, 2000.

Powers, F.M., Fogelson, B., Sturgeon, C., Solaro, R.J., and LAW, W.R. Depressed Myofilament Cooperativity Associated with Post-cardioplegic Myocardial Depression J. Mol. Cell. Cardiol. 30:1779-1787, 1998.

Farias, S., Powers, F.M., and LAW, W.R. End-diastolic Pressure-Volume Relationship in Sepsis: Relative Contributions of Compliance and Unstressed Chamber Volume Differ. J. Surg. Res. 82: 172-179, 1999.

Jacobson, G.M. and LAW, W.R. Verification of the Load-Independence of Tau and Its Use as an Indicator of Ventricular Relaxation.  Surgical Forum 1999.

Sharma, A.C., Fogelson, B.G., Nawas, S.I., Sam, A.D., II, Alden, K.J., Vigneswaran,W.T., Ferguson, J.L., and LAW, W.R. Increase in Coronary Effluent Endothelin-1 Concentration Following Reperfusion in Coronary Artery Bypass Grafting in Diabetic Patients. Ann. Thorac. Surg. 67: 1659-1663, 1999.

Fogelson, B.G., Nawas, S.I., Vigneswaran,W.T., Ferguson, J.L., LAW, W.R., and Sharma, A.C. Diabetic Patients Produce an Increase in Coronary Sinus Endothelin-1 after Coronary Artery Bypass Grafting. Diabetes 47: 1161-1163, 1998.