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Actinobacillus  actinomycetemcomitans
Virulence Factors of A. a.
FACTOR ACTION
Endotoxin Bone resorption
Unknown Bone resorption
Polyclonal antibody Stimulates an
stimulator inappropriate antibody
 response yielding
 excessive inflammation
It can inhibit normal cellular activity and can cause bone resorption via endotoxin production as well as via another unknown factor.
A polyclonal antibody stimulator causes an overreaction in immunologic response.  This amounts to the inflammatory process running amuck and causing much tissue destruction.
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