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Genome Characterization Centers and Genome Data Analysis Centers for The Cancer Genome Atlas Research Network (TCGA) [U24] RFA-Ca-09-010
Program Summary
This funding opportunity announcement (FOA) is designed to support The Cancer Genome Atlas (TCGA) research network. The overall goal of this phase of the TCGA initiative is to provide genome-wide catalogs of genomic alterations in 20-25 different types of human cancer that could be used to identify and accelerate the development of new diagnostic and prognostic markers, new targets for pharmaceutical interventions, and new cancer prevention and treatment strategies.
Under this FOA, the NCI solicits applications for two types of centers.
- Genome Characterization Centers (GCCs)
- Genome Data Analysis Centers (GDACs, that must be oriented on one of two permissible types of analytical pipelines)
GCCs will utilize novel high-throughput, high resolution technologies to comprehensively (i.e., genome-wide) detect genomic, epigenomic and transcriptome aberrations including: alterations in chromosome segment copy numbers, translocations, loss of heterozygosity, altered DNA methylation patterns and changes in gene expression, which may play a role in cancer.
GDACs will focus on the integration and analysis of data generated by the GCCs and other TCGA components, development of innovative bioinformatic and computational tools and the performance of advanced bioinformatic analyses including, but not limited to: systems biology approaches to discovery, pathway analysis models, and integrative data analysis methods with accompanying visualization tools to identify complex genomic changes; and integrated cancer biology and translational discovery models that will increase our understanding of cancer as a disease process. Prior contribution to the TCGA Pilot Project is not required and all qualified institutions and individuals are encouraged to apply to this FOA.
UIC may apply for one or two types of centers but- each applicant may submit only one application for a specific center type
- applicants must submit a separate application for each specific type/sub-type of center proposed (i.e., in aggregate, up to two applications are allowed).
Additional Information
http://grants.nih.gov/grants/guide/rfa-files/RFA-CA-09-010.html
Deadlines
| UIC Internal Letter of Intent (mandatory) | January 26, 2009 |
| UIC Internal Competition | TBD |
| Sponsor Letter of Intent | February 13, 2009 |
| Sponsor Full Proposals | March 13, 2009 |
Letter of Intent Instructions
- By submitting this form, applicant attests that s/he has read and meets the sponsor's eligibility criteria for this program. The LOI can be emailed to RDS@uic.edu, Attn:Jennifer Czak.
- OVCR may reserve submission slots for previously submitted but unfunded proposals that received highly competitive ratings from the external sponsor. These will be evaluated on a case-by-case basis by the Vice Chancellor. For consideration, scanned copies of your complete reviews (not just summary) must be included with LOI.
LOI form: http://tigger.uic.edu/depts/ovcr/research/funding/forms/0600.doc
Depending upon the number of LOIs submitted, OVCR might be required to facilitate an internal peer review process to select UIC’s submission(s) to this program. White paper instructions will be issued to those submitting LOIs, if necessary.
Please contact Jennifer Czak at jpaliga@uic.edu or 6-2590 with any questions.
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