Natural Products Science in Chicago - Products of Research and Education


				Products We aim to be productive in both the direct and the figurative sense. On one hand, we strive to generate interesting natural products and tools for natural products research. On the other hand, it is our goal to achieve scientific and academic excellence in academic research and education, and to make quality contributions to natural products science,especially pharmacognosy, by means of graduate education, postgraduate mentoring and training, and scientific publications. Research Our scientific research activities are carried out in the following units: Department of Medicinal Chemistry and Phamacognosy UIC/NIH Center for Botanical Dietary Supplement Research Institute for Tuberculosis Research Program for Collaborative Research on the Pharmaeutical Sciences Education Teaching in the Doctor of Pharmacy (PharmD) Program at UIC Teaching in the Ph.D. Graduate Programs in Pharmacognosy, in Medicinal Chemistry, and in the UIC MD/PhD Program Serving as Alternate Director of Graduate Studies in Pharmacognosy, Dept of Pharmacognosy of the Graduate College Elected member of the Awards Committee of the Graduate College PhD Graduates from the Pauli laboratory at UIC Lucas Chadwick, PhD (2004) Dissertation: "Estrogens and congeners from spent hops (Humulus lupulus) " [link to PDF file] Shixin Deng, PhD (2005) Dissertation: "Phtyochemical investigation of bioactive constituents from Angelica sinensis" [link to PDF file] Daniel Fabricant, PhD (2006) Dissertation: "Pharmacognostic investigation of black cohosh (Cimicifuga racemosa (L.) Nutt.)" [link to PDF file] Ryan Case, PhD (2006) Dissertation: "Integrative pharmacognostic evaluation of anti-TB ethnobotanicals from Manus" [link to PDF file] Allison Turner, PhD (2006) Dissertation: "The pharmacognosy of cranberries (Vaccinium macrocarpon) as a urological dietary supplement" [PDF file] Taichi Inui, PhD (2008) Dissertation: "Phytochemical and biochemometric evaluation of the Alaskan anti-TB ethnobotanical Oplopanax horridus" [PDF file] Prospective students interested in the UIC Ph.D. Graduate Program in Pharmacognosy, in particular those who are interested in joining our research group, are encouraged to download the pdf versions of the above dissertations to get an idea for some of the techniques used and for the type of research carried out in our laboratory. Please note that these are examples of graduate education rather than providing full coverage of all the ongoing research activities. Publications Below is a compilation of our publications since 2000, representing the most recent from a total of >70 peer-reviewed articles that report on our research and scholarly activity. Links: DOI links and/or links to their online abstracts and full-text versions are provided. For comprehensive coverage or to interface with bibliographic software, please query the NLM Medline database with the author term "pauli gf", search SciFinder with the author term "pauli guido f", or consult the BioInfoBank Library. ACS Articles On Request: Electronic pdf reprints of ACS Publications by GF Pauli; otherwise feel free to request reprints from the author. Note: Access to most journal articles and full DOI links require journal subscription and/or are subjected to user authorization. List of Recent Publications Nov 2007: ACS Highly Cited Article in JNP Chen S, Turner A, Jaki B, Nikolic D, van Breemen R, Friesen B, Pauli GF An Experimental Implementation of Chemical Subtraction Journal of Pharmaceutical and Biomedical Analysis (in press) (2008) Friesen B & Pauli GF Performance Characteristics of Countercurrent Separation in Natural Product Analysis Journal of Agricultural & Food Chemistry (in press) (2007) Overk C, Yao P, Chen SN, Imai A, Main M, Schinkovitz A, Pauli GF, Bolton J High-Throughput Screening and Mechanism-Based Evaluation of Estrogenic Botanical Extracts Combinatorial Chemistry and High-throughput Screening (in press) (2007) Friesen JB & Pauli GF Reciprocal Symmetry Plots as a Representation of Countercurrent Chromatograms. Analytical Chemistry 79: 2320-2324 (2007) Pauli GF, Niemitz M, Laitikainen R, Chen SN, Kleps R, Kozikowski A Complete 1H NMR Spectral Fingerprint of Huperzine A Magnetic Resonance in Chemistry 45: 878-882 (2007) Pang Y, Nikolic D, Zhu D, Chadwick L, Farnsworth N, Pauli GF, van Breemen R Binding of the Hop (Humulus lupulus L.) Chalcone Xanthohumol to Cytosolic Proteins in Caco-2 Intestinal Epithelial Cells. Molecular Nutrition & Food Research 51(7), 872-879 (2007) Farnsworth N, Krause E, Bolton J, Pauli GF, van Breemen R, Graham J UIC/NIH Center for Botanical Dietary Supplements Research for Women’s Health: from plant to clinical use American Journal of Clinical Nutrition (in press) (2007) Chen SN, Lankin DC, Nikolic D, Fabricant D, Lu ZZ, Ramirez B, van Breemen R, Fong HHS, Farnsworth NR, Pauli GF Chlorination Diversifies Cimicifuga racemosa Triterpene Glycosides Journal of Natural Products 70: 1016-1023 (2007) Deng S, Wang Y, Inui T, Chen SN, Farnsworth N, Cho S, Franzblau S, Pauli GF Anti-TB Polyynes from the Roots of Angelica sinensis Phytotherapy Research in press (2007) Berthod A, Friesen JB, Inui T, Pauli, GF Elution-Extrusion Countercurrent Chromatography: Theory and Concepts in Metabolic Analysis.[Featured article in May 2007, “Research Profile: Revisiting liquid stationary phases"] Analytical Chemistry 79: 3371-3382 (2007) Friesen JB, Pauli GF Rational Development of Solvent System Families in Counter-current Chromatography. Journal of Chromatography A 1151: 51-59 (2007). Inui T, Wang Y, Smith D, Franzblau S, Pauli GF Counter-Current Chromatography-Based Analysis of Synergy in an Anti-tuberculosis Ethnobotanical. Journal of Chromatography A 1151: 211-215 (2007). Cho SH, Warit S, Wan B, Hwang CH, Pauli GF, Franzblau SG Low Oxygen Recovery Assay (LORA) to rapidly screen for compounds active against non-replicating Mycobacterium tuberculosis. Antimicrobial Agents and Chemotherapy 51: 1380-1385 (2007) Case R, Wang Y, Franzblau SG, Matainaho L, Piskaut P, Soejarto D, Pauli GF Advanced Applications of CCC in the isolation of anti-TB constituents from Dracaena angustifolia. Journal of Chromatography A 1151: 169-174 (2007) Pauli GF, Jaki BU, Lankin DC A routine experimental protocol for qHNMR illustrated with taxol Journal of Natural Products 70: 589-595 (2007) Berthod A, Conway W, Ito Y, Pauli GF, Sutherland I CCC 2006 - The Fourth International Conference on Countercurrent Chromatography in Bethesda (MD): Natural Products and Scale-up Applications Journal of Chromatography A 1151: 1-5 (2007) Turner A, Chen SN, Nikolic D, van Breemen R, Farnsworth NR, Pauli GF Coumaroyl Iridoids and a Depside from Cranberry (Vaccinium macrocarpon) Journal of Natural Products 70: 253-258 (2007) Glodny B & Pauli GF The vasodepressor function of the kidney: further characterization of medullipin and a second hormone designated angiolysin Hypertension Research 29: 533-544 (2006) Deng S, Chen SN, Lu J, Wang ZJ, Nikolic D, van Breemen RB, Fong HHS, Farnsworth NR, Pauli GF GABAergic phthalide dimers from Angelica sinensis (Oliv.) Diels Phytochemical Analysis 17, 398-405 (2006) Glodny B & Pauli GF Preparation of a vasodepressor kidney medulla extract devoid of vasodepressor Prostaglandins [Editor’s choice article in July 2006, subtitled “Medullipin rises like Phoenix form the ashes?"] Acta Physiologica 187: 419-430 (2006) Guo J, Nikolic D, Chadwick L, Pauli GF, van Breemen R Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.) Drug Metabolism and Disposition 34: 1152-1159 (2006) He K, Pauli GF, Zheng B, Wang H, Bai N, Peng T, Zheng Q Cimicifuga species identification by high performance liquid chromatography-photodiode array/mass spectrometric/evaporative light scattering detection for quality control of clack cohosh products Journal of Chromatography A 1112: 241-254 (2006) Deng S, Chen SN, Yao P, Nikolic D, van Breemen R, Bolton J, Fong H, Farnsworth NR, Pauli GF Serotonergic activity-guided phytochemical investigation of the roots of Angelica sinensis Journal of Natural Products 69: 536-541 (2006) Case R, Franzblau SG, Wang Y, Cho S, Soejarto D, Pauli GF Ethnopharmacological evaluation of the informant consensus model on anti-tuberculosis claims among the Manus Journal of Ethnopharmacology: in press (2006) Jaki BU, Franzblau SG, Cho SH, Pauli GF Development of an extraction method for mycobacterial metabolome analysis Journal of Pharmaceutical and Biomedical Analysis 41: 196-200 (2006) Booth N, Chen SN, Overk C, Yao P, Bolton J, Pauli GF, Farnsworth NR Seasonal variation of red clover (Trifolium pratense L., Fabaceae) isoflavones Journal of Agricultural and Food Chemistry 54: 1277-1282 (2006) Chadwick L, Farnsworth NR, Pauli GF The pharmacognosy of Humulus lupulus L. (hops) with an emphasis on their estrogenic properties [Among the Top-25 of the most-accessed Phytomedicine articles] Phytomedicine 13: 119-131 (2006) Booth N, Overk C, Yao P, Burdette J, Nikolic D, Chen SN, Bolton J, van Breemen R, Pauli GF, Farnsworth N The chemical and biological profile of a red clover (Trifolium pratense) phase II clinical extract Journal of Alternative and Complimentary Medicine 12: 133-139 (2006) Glodny B & Pauli GF Medullopressin, a new short-acting pressor activity from the renal medulla. Hypertension Research 28: 827-836 (2005) Case R, Pauli GF, Soejarto D Factors in maintaining indigenous knowledge among ethnic communities of Manus Island, Economic Botany 59: 356-365 (2005) Friesen B & Pauli GF G.U.E.S.S. to make Generally Useful Estimations of Solvent Systems in CCC. Journal of Liquid Chromatography & Relat. Technologies 28: 2777-2806 (2005) Pauli GF, Case R, Inui T, Wang Y, Cho S, Fischer N, Franzblau S. New perspectives on natural products in TB drug research Life Sciences 78: 485-494 (2005) Pauli GF, Jaki B, Lankin D Quantitative 1H NMR: Development and potential of a method for natural products Analysis. [JNP/ACS Highly Cited Paper, ranking in the top 1% of the most-cited papers during the last 10 years.] Journal of Natural Products. 68: 133-149 (2005) Fabricant D, Nikolic D, Chen SN, Jaki B, Krunic A, Lankin D, van Breemen R, Farnsworth NR, Pauli GF Cimipronidine: A cyclic guanidine alkaloid from Cimicifuga racemosa (L.) Nutt. Journal of Natural Products 68: 1266-1270 (2005) Chen SN, Fabricant D, Pauli GF, Fong HHS, Farnsworth NR. 2005. Synthesis of Cimiracemate B, a phenylpropanoid found in Cimicifuga racemosa Natural Products Research 19: 287-290 (2005) Turner A; Chen SN, Joike M, Pendland S, Pauli GF, Farnsworth NR. 2005. A new adherence assay: Inhibition of uropathogenic E. coli by cranberry juice, Journal of Agricultural and Food Chemistry 53: 8940-8947 (2005) Dietz B, Kang YH, Liu G, Eggler A, Yao P, Chadwick L, Pauli GF, Farnsworth NR, Mesecar A, van Breemen R, Bolton J Xanthohumol Isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase [Among the Top-20 of the most-accessed CRT articles in III/2005] Chemical Research in Toxicology 18: 1296-1305 (2005) Overk C, Yao P, Chadwick L, Cuendet M, Fong HHS, Pauli GF, Farnsworth NR, Bolton J Comparison of the in vitro estrogenic activities of purified compounds from hops (Humulus lupulus) and red clover (Trifolium pratense) Journal of Agricultural and Food Chemistry 53: 6246-6253 (2005) Nikolic D, Li Y, Chadwick L, Pauli GF, van Breemen R Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids form hops, in human liver microsomes Journal of Mass Spectrometry 40: 289-299 (2005) Conway W, Chadwick L, Fong HHS, Farnsworth N, Pauli GF Extra-Column dead volume in countercurrent chromatography Journal of Liquid Chromatography and Related Technologies 28: 1799-1818 (2005) Seigler D, Pauli GF, Fröhlich R, Wegelius E, Nahrstedt A, Glander K, Ebinger J Cyanogenic clycosides and menisdaurin from Guazuma ulmifolia, Ostrya virginiana, Tiquilia plicata, and Tiquilia canescens Phytochemistry 66: 1567-1580 (2005) Chadwick L, Fong HHS, Farnsworth NR, Pauli GF CCC sample cutting for isolation of prenylated phenolics from hops Journal of Liquid Chromatography and Related Technologies 28: 1959-1969 (2005) Inui T, Case R, Chou E, Soejarto D, Fong HHS, Franzblau S, Smith D, Pauli GF. 2005. Anti-TB ethnobotanicals and plants from alaska and asia - The potential of CCC Journal of Liquid Chromatography and Related Technologies 28: 2017-2028 (2005) Dietz B, Fey S, Pauli GF, Farnsworth NR, Mahady G Valerian extract and valerenic acid are partial agonists of the 5HT5A-receptor in vitro Molecular Brain Research 138: 191-197 (2005) Ma C, Case C, Wang Y, Zhang H, Tan G, Van Hung N, Cuong N, Franzblau S, Soejarto D, Fong H, Pauli GF Anti-tuberculosis compounds from Micromelum hirsutum Planta Medica 71: 261-267 (2005). Chadwick L, Fröhlich R, Chen S, Bolton J, van Breemen R, Overk C, Burdette J, Nikolic D, Fong H, Farnsworth N, Pauli GF Estrogens and congeners from hops (Humulus lupulus). Journal of Natural Products 67: 2024-2032 (2004). Jaki B, Franzblau S, Pauli GF An NMR method towards routine chiral determination of natural products Phytochemical Analysis 15: 213-219 (2004). Seigler DS, Pauli GF, Nahrstedt A, Leen R Cyanogenic allosides and glucosides from Passiflora edulis and Carica papaya, Phytochemistry 60: 873-882 (2003). Jaki B, Sticher O, Veit M, Fröhlich R, Pauli GF Evaluation of glucoiberin reference material from Iberis amara by spectroscopic fingerprinting Journal of Natural Products 65: 517-522 (2002). Pauli GF qNMR - A versatile concept for the validation of natural product reference compounds Phytochemical Analysis 12: 28-42 (2001). Fröhlich R & Pauli GF alpha-Onocerin Acta Crystallographica C 56: 1476-1477 (2001). Pauli GF Higher order and substituent chemical shift effects in the proton NMR of glycosides Journal of Natural Products 63: 834-838 (2000).
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