Applications of qNMR

1. qNMR Using Time Domain Data

Quantitative Analysis of Process NMR Signals in the Time Domain by A. Nordon, C.Mc Gill, P. Gemperline, D. Littlejohn; poster at the 2001 CPACT Conference. The authors use algorithms such as FID-DECRA to perform qNMR directly from the FID

2. qHNMR of Residual Solvents

Residual solvents can be simultaneously identifiied and quantified by NMR spectroscopy. In a very recent publication, Jones, Sharman, and Pidgeon have published an excellent approach using a html/xml and java-based small database that allows the rapid identification of signals of all ICH-prescribed solvents. This forms the basis of rapid and reliable qHNMR quantification of even trace quantities of solvents in e.g. pharmaceutical samples.

Jones, Ian C; Sharman,Gary J; Pidgeon, Julia. 1H and 13C NMR data to aid the identification and quantification of residual solvents by NMR spectroscopy. Magn. Res. Chem. 2005, 43, 497-509 (http://dx.doi.org/10.1002/mrc.1578).

3. Reference Materials

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4. Reports on qNMR Methodology

• Improvement of Integration in 1D HNMR and CNMR

5. Potential Applications of qNMR

Reported areas of application of the qNMR toolbox include, but are not limited to,

• Drug Discovery
• Drug Development
• Quality Control
• Natural Products Chemistry
• Reference Substances
• Herbal Dietary Supplement Research (Phytopharmacy)
• Pharmaceutical Analysis
• Regulatory Affairs