qXNMR - qNMR with Nuclei other than Protons and Carbons

Additional supporting information for the 2007 publication in the Journal of Natural Products on routine qHNMR

Besides protons and carbons, other nuclei amenable to NMR spectrocsopy can be used for quantitative analysis. The foremost examples are 31P representing a nucleus found in a myriad of phosphorylated metabolites, and 19F found in numerous drug molecules containing stabile -F and -CH3 functional groups.

Literature covering the qXNMR analysis of these nuclei is currently sparse:

qFNMR

• Martino, R.; Gilard, V.; Desmoulin, F.; Malet-Martino, M. Fluorine-19 or phosphorus-31 NMR spectroscopy: a suitable analytical technique for quantitative in vitro metabolic studies of fluorinated or phosphorylated drugs. J. Pharm. Biomed. Anal. 2005, 38, 871-891.

qPNMR

• Martino, R.; Gilard, V.; Desmoulin, F.; Malet-Martino, M. Fluorine-19 or phosphorus-31 NMR spectroscopy: a suitable analytical technique for quantitative in vitro metabolic studies of fluorinated or phosphorylated drugs. J. Pharm. Biomed. Anal. 2005, 38, 871-891.