qNMR - The Mag[net]ic Research ToolNuclear Magnetic Resonance (NMR) is a powerful spectroscopic tool that is widely used in structural analysis. While the majority of NMR applications is qualitative, quantitative NMR (qNMR) represents a metrological method of analysis with unique capabilites. The particular power of quantitative NMR arises from several properties: qNMR offers a unique physicochemical view of the analyte based on nuclear magentism, qNMR is a primary analytical method, and qNMR yields qualitative and quantitative information simultaneously. Thus, qNMR is a versatile tool for research projects at the chemistry-biology interface. Quantitative 1H NMR (qHNMR) has recently been gaining popularity in the analysis of complex natural products such as botanicals dietary supplements. An update of our 2005 review on qHNMR analysis of natural products, published in the Journal of Natural Products, is currently being prepared and will appear soon. The update will cover the literature from 06/2004-12/2011.
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RECENT PAPERS
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Assessment of Residual |
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The Tandem of Full Spin Analysis and qHNMR for the Quality Control of Botanicals Exemplified with Ginkgo biloba |
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qNMR Background
- qNMR History: Anecdotal qNMR
- qNMR Theory: Routine qHNMR, qNMR Review
- qNMR Applications: Purity-Activity Relationships (PARs), ICH-prescribed residual solvents, fatty acids
qNMR Research at UIC
- development of qNMR methodology for natural products analysis
- Assessment of purity and integrity of pharmaceutical and botanical preparations
qNMR Resources
- qNMR Support:
- qHNMR experiments: 1H qNMR (qHNMR) for Bruker, Jeol, and Varian
- qXNMR experiments: qCNMR, 19F qNMR (qFNMR), 31P qNMR (qPNMR)
- qNMR reference materials
- qNMR Literature: research articles, comprehensive review on qHNMR
- qNMR Links: PERCH qNMR course , UCR qNMR eLearning Module
- Useful NMR Links: NMR Basics
qNMR Resources at UIC
Our group has an extensive track record and expertise in developing qNMR experimental techniques, with a focus on the 1H variant of qNMR (qHNMR), and capabilities for 13C and 31P qNMR analysis.
- Our Team of qNMR Experts at UIC, College of Pharmacy
- Our Natural Products Group at UIC and at the College of Pharmacy
Quantitative 1H NMR: development and potential of a method for natural products analysis
Pauli/Lankin/Jaki
Journal of Natural Products
2005, J.Nat.Prod.
(2012 update coming)
Integrated Standardi-
zation Concept for
Angelica Botanicals
using qHNMR
Gödecke et. al
Fitoterapia
2012, 83(1) 18-32
Routine qHNMR Protocol
Bruker, Varian, Jeol
Support
Pauli/Jaki/Lankin
J. Nat. Prod.
2007, 70(4) 589-95