TABLE OF CONTENTS
| CHAPTER | DESCRIPTION
OF CONTENTS |
|---|
| 0 | Introduction
|
| 1 |
Hybridization, valence angles and bond lengths: Hybrid
orbitals (carbon, sp3, sp2, sp); hybridization of
nitrogen, oxygen, phosphorus; bond lengths, angles and energies. |
| 2 | Symmetry elements: Center of symmetry;
plane of symmetry; axis of symmetry. |
| 3 | Graphical representation of nonplanar
molecules:
Fisher projection; wedge projection; Newman projection; sawhorse
projection; Haworth projection; stereodiagrams |
| 4 | Interaction of drugs with biological
matrices: Effect of chirality (enantiomerism). |
| 5 | Rules for specification of chirality:
Cahn-Ingold-Prelog rules; ligand precedence rules; helical chirality; Z/E
geometry of double bonds; cis/trans geometry of alicyclic compounds;
relative configurations in compounds with multiple chiral centers; meso
compounds and pseudoasymmetry; chiroptical properties. |
| 6 |
Conformation: Conformation; nomenclature; conformational
energy and equilibria (sp2, amide bonds, ester bonds, anomeric
effects); conformation of ring compounds (six-membered rings,
cyclohexane and cyclohexene, five-membered rings, anomeric effect). |
| 7 | Practice exams: Comprehensive
problems and sample exams. |
