I. DISCOVERY AND DEVELOPMENT OF SYNTHETIC AND NATURAL DRUGS (Cordell)
2. Modern drug discovery and the pharmaceutical industry (08/26).
3. Drugs of the future (08/27).
"ASSESSMENT" TEST, 2.30-3.30 PM., Tues. 08/26, Rm. 134-2 and 134-3
4. Hybridization (08/28).
5. Structure, properties and nomenclature of functional groups found in biopolymers and drugs (09/02).
6. Structure of heteroarenes found in biopolymers and drugs (09/03).
7. General principles of acid-base chemistry (09/04).
8-9. Acid-base properties of functional groups found in biopolymers and drugs (heteroarenes and amino acids) (09/08-09/09).
10-11. Nucleophilic vs. electrophilic properties of functional groups found in biopolymers and drugs (09/10-09/11).
RECITATIONS, 1.30-3.30 PM., Tues.-Thur., 09/02-09/04 (Cordell and Kim) and 09/09-09/11 (Kim) (see section and TA assignment, 5th floor display case).
EXAM I (lectures 1-11), 2.30-3.30 PM., Thur., 09/18, Rm. 32 & 36, 150 pts
12. Chemical reactivity of ester, amide and acetal bond (09/15).
13-14. Specific reactions of heteroarenes and other functional groups (09/16-09/17).
15. Chemistry of phosphate group (09/18).
16. Chemistry of carbohydrates, oligo- and polysaccharides (09/22).
17. Combination of heteroarenes, glycosides and phosphate: nucleosides and nucleotides (09/23).
18. Reactivity of nucleic acids: hydrolysis, oxidation and alkylation of nucleic acid (09/24). REDOX CHEMISTRY (Bruzik)
19. Principles of REDOX systems (09/25).
20. Catalytic mechanisms of enzyme cofactors (09/29).
RECITATIONS, 1.30-3.30 PM. Tues.-Thur. 09/23-09/25 (Kim and Bruzik)
EXAM II (lectures 12-20), 2.30-3.30 PM., Thur., 10/09, Rm. 32 & 36, 150 pts
21. Three point recognition (09/30).
22. Concepts and nomenclature of stereoisomerism, chirality and configuration (10/01).
23. Three dimensional shape of molecules: conformation (10/02).
24. Conformation of ester, amide, phosphate, and six-and five-membered ring systems
(10/06).
RECITATIONS, 1.30-3.30 PM., Tues.-Thur., 09/30-10/02 (Bruzik)
25. Introduction: Natural products from plants, microorganisms and marine sources (10/07).
26. Classification of natural product drugs: Alkaloids I (10/08).
27. Alkaloids II (10/09).
28 Isoprenoids (10/13).
29 Phenols and Quinones (10/14).
30. Introduction to phytopharmaceuticals (herbal remedies) (10/15).
RECITATIONS, 1.30-3.30 PM. , Tues.-Thur. 10/14-10/16 (Kinghorn)
MIDTERM, 2.30-3.30 PM. Thur., 10/23, Rm. 32 & 36, 200 pts
31. Noncovalent interactions: hydrogen bonding, electrostatic interactions, hydrophobic effect (10/16).
32-33. Peptide and protein structure (10/20-10/21).
34. Nucleic acid structure (10/22).
35. Membrane structure (10/23).
36. Lipid-drug delivery systems (10/27).
RECITATIONS, 1.30-3.30 PM., Tues.-Thur., 09/28-09/30 (Hopfinger)
37. Cellular Structures: Classification of organisms. Prokaryotic and eukaryotic cell structure (10/28).
38. Membrane transport: Electrochemical potential. Active and passive transport (10/29).
39. Pumps. Na+/K+ ATPase. Ca2+ pumps. Ionophores (10/30).
40. Channels and pores. Ligand and voltage-gated channels. Nerve impulse (11/03)
41. Signal transduction cascades: Cell cycle. Vision (11/04).
42-43. Hormones and secondary messengers (11/05-11/06).
RECITATIONS, 1.30-3.30 PM., Tues.-Thur., 11/04-11/06, (Blond)
EXAM IV (lectures 31-40) 2.30-3.30 PM., Thur. 11/13, Rm. 32 & 36 (Hopfinger and Blond), 150 pts
44. Central dogma and genetic code: Principles of storage and expression of genetic information. Genetic code (11/10).
45. Replication and transcription. RNA processing and transport (11/11).
46. Protein synthesis. Ribosome. Inhibitors of translation (11/12).
47. Eukaryotic and bacterial genomes:Genome size. Introns. Gene families. "Junk DNA". Concept of "selfish DNA" (11/13).
48. Viruses: Viruses as autonomous genetic systems. Viruses as selfish DNA (11/17).
49. Autonomous genetic elements: Replication origin and telomers. Replication of
bacterial and eukaryotic chromosomes. Plasmids. Recombination (11/18).
RECITATIONS, 1.30-3.30 PM. Tues.-Thur. 11/18-11/20 (Mankin and Neyfakh)
EXAM V (lectures 41-49), 2.30-3.30 PM., Tues., 11/25, Rm. 32 & 36 (Blond and Neyfakh) (Note the change of the exam day), 150 pts
50. Mechanisms of gene regulation: Operons. Positive and negative regulation of transcription (11/19).
51. Transcription factors. Enhancers. Regulation of translation (11/20).
52. Mechanisms of cell differentiation and development(11/24).
53. Cancer as a gene regulation disease (11/25).
54. Gene cloning: Enzymes used in gene cloning. Restriction enzymes. DNA ligase. DNA polymerase (11/26).
55. Plasmids and viruses as cloning vectors (12/01).
56. Transformation and selection of transformed cells. Gene libraries (12/02).
57. PCR: The principle of PCR method (12/03).
58. Application of PCR. Gene Cloning. Diagnostics. Forensics (12/04).
RECITATIONS, 1.30-3.30 PM., Tues.-Thur., 12/02-12/04, (Neyfakh and Mankin)
FINAL EXAM, time and date to be assigned by the College, 200 pts