Name: Leo Miller, Professor Emeritus

University Address:	Home Address
Dept. of Biological Sciences (m/c 066)	204 Parkview Rd
University of Illinois at Chicago	Riverside, IL 60546
845 W. Taylor, Chicago, IL. 60607	Telephone 708-442-2519, Email leo@uic.edu

Education

1968 Ph.D. University of Rochester

1964 M.S. State University of New York at Albany

1962 B.S. State University of New York at Brockport

Professional Experience

2003 Adjunct Professor, Spring Semester, Florida Atlantic University, Dept. of Biological Sciences, Boca Raton, FL

2002 Adjunct Professor, Spring Semester, Florida Atlantic University, Dept. of Biological Sciences, Boca Raton, FL

2001 Adjunct Professor, Summer Semester, University of Alaska Fairbanks, Dept. of Biology and Wildlife, Fairbanks, AK

2001 Adjunct Professor, Spring Semester, New College of Florida, Division of Natural Sciences, Sarasota, FL

2001 Professor Emeritus, Dept. of Biological Sciences, University of Illinois at Chicago

1993-2000 Professor, Dept. of Biological Sciences, University of Illinois at Chicago

1980-1993 Associate Professor, Dept. of Biol. Sciences, University of Illinois at Chicago

1977-80 Assistant Professor, Dept. of Biol. Sciences, University of Illinois at Chicago

1971-77 Assistant Professor, Dept. of Anatomy, Northwestern University Medical School

1970 Research Associate, State University of New York at Buffalo

1968-70 USPHS Postdoctoral Fellowship, Oxford University, Oxford, England

Honors, Awards, and Fellowships

Best Teacher Award, Biology Colloquium, 1998

University Teaching Recognition Award, 1997

Teaching Recognition Award, Biology Colloquium, 1995

USPHS Postdoctoral Fellowship from National Cancer Institute, Oxford University (J.B. Gurdon, advisor), 1968-70

Teaching Experience

Undergraduate Courses (taught as an Adjunct Professor after retirement from UIC)

Cell Biology at New College of Florida

Fundamentals of Biology II at the University of Alaska, Fairbanks

Life Sciences (for non-majors) at Florida Atlantic University

Undergraduate Courses at the University of Illinois

LAS 100 Freshman Seminar: Introduction to University Study

CC 100 Freshman Success Seminar

BIOS 100 General Biology: The Biology of Cells

BIOS 103 Human Development and Reproduction

HON 201 Honors College Seminars

BIOS 220 Mendelian and Molecular Genetics

BIOS 325 Vertebrate Embryology

Graduate Courses at the University of Illinois

BIOS 448 Chromosome Structure and Function

BIOS 525 Molecular Biology II

BIOS 526 Molecular and Genetic Analysis of Development

BIOS 594 Special Topics in Biological Sciences

BIOS 596 Topics in Molecular Biology: Determination and Differentiation

Description of courses which constitute my major teaching responsibilities at UIC

BIOS 103: Human Development and Reproduction. Class Home Page http://www.uic.edu/~leo/bios103.html 5 credit hours, lecture, discussion and laboratory course. Elective which meets university requirements for Natural Science Course Distribution Credit. The course is always filled to capacity (250 students).

I developed this course for undergraduates who are not Biology majors. To facilitate discussion and make feedback a little easier I divide the class in half by teaching 2 sections. Many of the topics have been selected because they are inherently interesting and are relevant to the students lives. This provides an engaging context to teach basic biological principles, the students are more interested in learning and they remember more of the material. I feel it is important to present a universal view of each topic and involve the students in different styles of learning. For example, I lecture on the biology of the mammary gland, including its cell biology, physiology and development. I also lecture on the biology of breast cancer and show a video on the human impact of this cancer, the role of genetic counseling and genetic tests. We then have a Discussion/Lab in which a volunteer from La Leche League talks about breast feeding. Lastly, the students have the option of taking part in the "Race for the Cure" to fulfill the course field trip requirement. Last year over 100 students participated.

Other topics I cover include in vitro fertilization, cloning, human embryonic stem cell lines, fetal tissue transplantation, genetic engineering of human cells and gene therapy. I teach the basic biological principles in the context of life. Many of these topics have challenged our views of parenthood, family, and personal identity and have raised a number of ethical, religious and legal issues which we must confront. While I emphasize the basic scientific principles of embryology and reproduction in this course I also spend time discussing how the biology is relevant to confronting these ethical issues. My goal is to help students become critically thinking, scientifically literate citizens, ready to make informed decisions about issues related to human development, health and reproduction.

BIOS 325: Vertebrate Embryology. Class Home Page http://www.uic.edu/~leo/bios325.html
5 credit hours, lecture and laboratory course. Elective for the Biology Major. Mainly juniors and seniors with majors in biology or health science programs. Enrollments (100-150 students) are limited by the number of laboratory sections offered, but the course is always filled to capacity.

The study of vertebrate embryo development has recently taken on added significance due to advances such as in vitro fertilization, fetal tissue transplantation, embryonic stem cells and cloning. The accessibility of the human embryo in vitro, combined with advances in molecular biology has also opened the door for genetic engineering, and tissue and gene therapy. These embryological advances have also raised a number of ethical, religious and legal issues which we discuss in class. My goal is to help students understand the basic biological principles of embryology and how they are relevant to making informed choices about these issues, how human development is similar to the development of other vertebrates and how abnormalities in developmental processes can lead to congenital defects.

Administrative Responsibilities

Graduate Program Director, 1997-2000

Undergraduate Program Director, 1992-1996

Graduate Program Director, 1980-1986

Chair, Developmental Biology Search Committee, 1991-1994

Chair, Mammalian Physiology Search Committee, 1983-84

Other Professional Activities

Campus-wide

1998		Teaching Recognition Awards Health Sciences Review Committee
1998		Sigma XI, Judge
1996-99		Individual Plan of Study Committee
1995-97		Faculty Advisory Committee
1989-95, 96-2000		Honors College Fellow
1989-96		UIC Senate
1985-88		Awards Committee of Graduate College
1986-87		Selection Committee for Minorities Fellowships, Graduate College
1989-90		UIC, Dental School, Oral Biology Consolidation Committee

Departmental

1997-2000		Introductory Biology Committee
1997-2000		Web Master, Graduate Program
1995-2000		Advisory Committee
1992-2000		Ad hoc Executive Committee
1992-93		Eukaryotic Developmental Biology Search Committee
1991-92		LMB Graduate Student Recruitment Committee
1991-92		Signal Transduction Search Committee
1989-91		Molecular Geneticist Search Committee
1990-91		Cell & Development Admissions Committee
1988-89, 90-91		LMB Admissions and Policy Committee
1978-88, 90-91		Animal Care Committee (Chairman, 1985-86)
1988-90		Departmental Seminar Committee (Chairman, 1988-89)
1989-90		LMB Graduate Recruitment Committee
1988-89		LMB Seminar Committee (Chairman, 1988-89)
1988-89		LMB First Year Review Committee
1988-89		LMB Postdoctoral Fellowship Committee
1987-88		LCMDB Student Seminars
1985-86		Physiology Search Committee
1985-86		LCMDB Graduate Fellowship Awards Committee
1983-85, 81-82,99-00		Promotion and Tenure Subcommittee, Asistant to Associate Professor
1983-84		Eukaryotic Chromosome Search Committee
1981-86		Space Committee
1980-86		Ad Hoc Executive Committee
1979-86		Electron Microscope Committee
1980-81		Behavioral Biology Search Committee
1978-79		Undergraduate Committee
1978-79		Molecular Evolution Search Committee
1977-78		Physiology Search Committee

Extramural

Illinois Articulation Initiative, 1995-96
Manuscript Reviewer for BioTechniques, Development, Developmental Biology, Developmental Genetics, Differentiation, Experimental Cell Research, Journal of Cell Biology, Molecular Endocrinology, Science 

Grant Support

3/98-3/99		University of Illinois Campus Research Board, "The Role of Homeobox Gene Expression in Skin Development", $15,000.
6/98-8/98		Summer Course Enhancement Award, Genetics BioS 220, $1,000.
6/97-8/97		Summer Course Enhancement Award, Vertebrate Embryology BioS 325, $1,000.
12/95-12/96		University of Illinois Campus Research Board, "Regulation of Keratin Gene Expression during Metamorphosis", $8,000.
1/94-7/94		University of Illinois Campus Research Board, "Hormonal Control of Gene Expression during Development", $8,000.
8/88-7/93		National Institutes of Health, NICHHD, "Keratin Gene Expression During Xenopus Development", $411,345.
3/88-3/89		University of Illinois Biomedical Research Board, "Role of the Dermis in Differentiation of the Epidermis", $7,000.
11/86-10/87		National Science Foundation, "Application for Transmission ElectronMicroscope" (joint application), $84,500.
6/85-5/86		University of Illinois Biomedical Research Board, "Developmental Regulation of Keratin Genes", $5,546.
7/84-8/84		University of Illinois Biomedical Research Board, "Shared Equipment for DNA Sequencing" (joint application), $2,120.
12/83-8/84		University of Illinois Biomedical Research Board, "Isolation of Keratin Genes of Xenopus laevis", $4,000.
7/80-6/81		University of Illinois Research Board, "Messenger RNA Metabolism in Growing and Resting Cells", $3,865.
5/80-4/81		National Science Foundation, "Application for Scanning Electron Microscope" (joint application), $70,000.
6/79-12/79		University of Illinois Research Board, "Regulation of Cell Growth In Vitro", $2,550.
7/78-6/79		University o f Illinois Research Board, "Regulation of RNA Synthesis in Xenopus laevis", $4,000.
7/78-6/7		University of Illinois Research Board, "Ribosomal RNA Synthesis in Nucleolar Mutants of Xenopus laevis", $3,730.
1/78-4/7		National Science Foundation, "Messenger RNA Synthesis in Nucleolar Mutants of Xenopus", $15,560.
73/76-8/78		National Science Foundation, "Messenger RNA Synthesis in Nucleolar Mutants of Xenopus", $50,000.
6/76-6/77		Northwestern University Research Board, "Messenger RNA Synthesis in Xenopus laevis", $2,440.
6/75-9/75		Northwestern University Research Board, "Messenger RNA Synthesis in Xenopus laevis", $1,100.
7/75-6/76		Northwestern University Research Board, "Ribosomal RNA Synthesis in Xenopus laevis", $4,074.
5/73-10/73		National Science Foundation, "Ribosomal RNA Synthesis in Nucleolar Mutants of Xenopus laevis", $45,000.
1/72-12/73		Northwestern University Research Board, "Ribosomal RNA Synthesis in Xenopus laevis", $9,000.

 

Publications

1999		Warshawsky, D. and L. Miller. Mapping Protein-DNA Interactions Using In Vivo Footprinting. In: Molecular Methods in Developmental Biology, Xenopus and Zebrafish, M. Guille, ed. Humana Press, 127:199-212.
1997		Warshawsky, D. and L. Miller. In vivo footprints are found in the Xenopus 63kDa keratin gene promoter prior to the appearance of mRNA. Gene 189: 209-212.
1997		Nishikawa, A., K. Shimizu-Nishikawa, and L. Miller. Isolation and culture of larval and adult epidermal cells of the frog, Xenopus laevis. In: Cell and Tissue Culture: Laboratory Procedures, J.B. Griffiths, A. Doyle and D.G. Newell, eds., John Wiley and Sons, Ltd., West Sussex, England, 23B:1-14
1996		Miller, L. Hormonal induced changes in keratin gene expression during amphibian metamorphosis. In "Metamorphosis: Post-Embryonic Reprogramming of Gene Expression in Amphibian and Insect Cells," L.I. Gilbert, B.G. Atkinson, and J.R. Tata (eds.), Academic Press, pp. 599-624.
1995		Warshawsky, D. and L. Miller. Tissue-specific in vivo protein-DNA interactions at the promoter region of the Xenopus 63 kd keratin gene during metamorphosis. Nucleic Acids Research 23(21): 4502-4509.
1994		Warshawsky, D. and L. Miller. A rapid genomic walking technique based on ligation mediated PCR and magnetic separation technology. Bio Techniques 16: 792-798.
1994		French, R.P., D. Warshawsky, L. Tybor, N. Mylniczenko and L. Miller. Upregulation of AP-2 in the skin of Xenopus laevis during thyroid hormone-induced metamorphosis. Develop. Genetics 15: 356-365.
1992		Nishikawa, A., K. Shimizu-Nishikawa, and L. Miller. Spatial, temporal, and hormonal regulation of epidermal keratin expression during development of the frog, Xenopus laevis. Dev. Biol. 151: 145-153.
1992		Shimizu-Nishikawa, K. and L. Miller. Calcium regulation of epidermal cell differentiation in the frog, Xenopus laevis. J. Exp. Zool. 260: 165-169.
1991		Shimizu-Nishikawa, K. and L. Miller. Hormonal regulation of adult type keratin gene expression in larval epidermal cells of the frog, Xenopus laevis. Differentiation 49: 77-83.
1990		Nishikawa, A., K. Shimizu-Nishikawa and L. Miller. Isolation, characterization and in vitro culture of larval and adult epidermal cells of the frog Xenopus laevis. In Vitro Cell. Dev. Biol. 26: 1128-1134.. 260: 165-169.
1989		Mathisen, P.M. and L. Miller. Thyroid hormone induces constitutive keratin gene expression during Xenopus development. Molecular and Cellular Biology 9: 1823-1831.
1987		Mathisen, P.M. and L. Miller. Thyroid hormone induction of keratin genes: a two-step activation of gene expression during development. Genes and Development 1: 1107-1117.
1985		Ellison, T.A., P.M. Mathisen and L. Miller. Developmental changes in keratin patterns during epidermal maturation. Develop. Biol. 112: 329-337.
1983		Law, R.E. and L. Miller. Effect of 5'methylthioadenosine on RNA and DNA synthesis in cultured Xenopus laevis cells. Exp. Cell Res. 147: 461-465.
1982		Budorick, N.E. and L. Miller. Parallel changes in protein synthesis and messenger RNA content in growing and resting epithelial cells of Xenopus laevis. J. Cell Physiol. 111: 284-290.
1981		Law, R.E. and L. Miller. Effect of 5'-methylthioadenosine on nucleolar morphology and RNA metabolism in cultured Xenopus laevis cells. Exp. Cell Res. 135: 435-438.
1979		Martin, A.O., L. Miller, J.L. Simpson, C. Thomas, M.R. Rzeszotarski, S. Elias, G.E. Sarto and V.A. Patel. Localization of the nucleolar organizer by computer-aided analysis of a variant No. 21 chromosome in a human isolate. Human Genetics 48: 211-220.
1979		Miller, L. A detergent-citric acid technique for isolating nuclear and cytoplasmic fractions containing undegraded RNA from cells of Xenopus laevis. Anal. Biochem. 100: 166-173.
1978		Miller, L. Relative amounts of newly synthesized poly (A)+ and poly (A)- messenger RNA during development of Xenopus laevis. Dev. Biol. 64: 118-129.
1977		Miller, L. and J.C. Daniel. Comparison of in vivo and in vitro ribosomal RNA synthesis in nucleolar mutants of Xenopus laevis. In Vitro 13: 557-564.
1976		Miller, L. and F. Gonzales. The relationship of ribosomal RNA synthesis to the formation of segregated nucleoli and nucleolus-like bodies. J. Cell. Biol. 71: 939-949.
1974		Miller, L. Metabolism of 5S RNA in the absence of ribosome production. Cell 3: 277-283.
1973		Miller, L. Control of 5S RNA synthesis during early development of anucleolate and partial nucleolate mutants of Xenopus laevis. J. Cell Biol. 59: 624-632.
1972		Miller, L. Initiation of ribosomal RNA precursor synthesis in different regions of Rana pipiens gastrulae. Biochem. J. 127: 733-735.
1970		Miller, L. and J. Knowland. The number and activity of ribosomal RNA genes in Xenopus laevis embryos carrying partial deletions in both nucleolar organizers. Biochemical Genetics 6: 65-73.
1970		Miller, L. and J.B. Gurdon. Mutations affecting the size of the nucleolus in Xenopus laevis. Nature 227: 1108-1110.
1970		Knowland, J. and L. Miller. Reduction of ribosomal RNA synthesis and ribosomal RNA genes in a mutant of Xenopus laevis which organizes only a partial nucleolus. I. Ribosomal RNA synthesis in embryos of different nucleolar types. J. Mol. Biol. 53: 321-328.
1970		Miller, L. and J. Knowland. Reduction of ribosomal RNA synthesis and ribosomal RNA genes in a mutant of Xenopus laevis which organizes only a partial nucleolus. II. The number of ribosomal RNA genes in animals of different nucleolar types. J. Mol. Biol. 53: 329-338.
1969		Miller, L. and D.D. Brown. Variation in the activity of nucleolar organizers and their ribosomal gene content. Chromosoma 28: 430-444.