Ecology and Evolution
Mohammed Abdul
Quddus Khan
Professor
Ph.D. University of
Western Ontario, London, Canada
I obtained my Ph.D. in 1964 from the University of Western Ontario,
London, Canada. My thesis research was on the genetics of insecticide resistance
in mosquitoes. I spent four years as a postdoctorate at North Carolina
State University, Oregon State University, and Rutger-The State University
of New Jersey. I joined UIC in 1969 to teach animal physiology and do research
in environmental toxicology. During my stay here I also spent a year at
N.I.H. (1975-76) as a Visiting Scientist, one year at UAE University (1992-93)
as a Fulbright Scholar. Besides these, I spent summers at University of
Wisconsin, Madison (1970), USEPA (1980), Corvallis, Oregon, two 2-month
periods with United Nations Development Program.
My laboratory has been involved in research in environmental toxicology.
This has included several aspects of ecotoxicology and health effects of
environmental chemicals, especially chlorinated cyclodiene insecticides,
heavy metals, and polycyclic aromatic hydrocarbons. The major projects
are as follow.
I. CHLORINATED INSECTICIDES.
Studies of the environmental fate and effects of cyclodiene insecticides
showed that the residues of some of these insecticides can be photolyzed
to more toxic products. The photoisomers of some of these cyclodienes become
4- to 30-time more toxic to vertebrates and 2- to 265-time more toxic to
aquatic foodchain organisms. Elaborate investigations on biotransformations
of these photoisomers showed that they can be converted to ore toxic products
in the body. Further studies showed that the parent cyclodienes are more
potent inducers of liver hypertrophy and induction of P450 isozymes. These
are more potent inhibitors of the CNS GABA-A chloride channel complex.
This work has resulted in about 50 papers and about 20 book chapters
and review articles. Several national and international symposia organized
by me resulted in four volumes of symposia proceedings. These will be listed
at the end of this project description.
Following persons obtained their training on this project.
1. Andrew A. Podowski, PhD (1989), currently at USEPA, Chicago
Publications
1.1970a M.A.Q. Khan, D.J. Sutherland, J.D. Rosen and W.F. Carey. Effect
of sesamex
II. LIVER STRUCTURE AND BIOCHEMISTRY
Chlorinated organic chemicals, including cuclodienes, cause liver hypertrophy
and induction of hepatic microsomal P450 isozymes. The effects of photoisomers
of cyclodienes were compared with those of their parent chemicals and model
inducers using rats and fish as experimental species. These studies include
ultrastructural changes, biochemical alteration, activities of various
P450 isozymes, and hormonal changes involved in these manifestations.
The persons associated with those project are identified
as follows.
1. Lela V. Jovanovich, PhD (1987), currently at Wastemeanagements, Westmont
Publications
1. 1985 M.A.Q. Khan, P. Sudershan, and A.A. Podowski, Significance of
III. CYTOCHROME P450 OXYGENASES
A comparative study of the hepatic microsomal P450 isozymes has been
carried out in vertebrates and insects. This has included biochemical mechanisms
underlying induction of these enzymes in mammals as well as the genetics
of these enzymes in insects.
The following students contributed to this project.
1. Richard H. Stanton, Ms (1974), PhD (1976), currently at Chevron Chemicals
undergraduates: several undergraduates contributed to this research.
Most of these are now MDs. One of these is a distinguished scientist (Dr.
R.I.Morimoto, Dean of LAS, Northwestern University)
Publications
1. 1972c M.A.Q. Khan, W. Coello, A.A. Khan and H. Pinto. Some
characteristics of the
IV. HEAVY METAL TOXICITY
This work has included the effects of temperature on heavy metal toxicity
to aquatic animals as well as the chelation of heavy metals with keratins
in hair, scales, and feathers.
The persons associated with this project are as follows.
1. Walter F., Coello, Res. Assistant
Publications
1. 1973d M.A.Q. Khan, W.F. Coello, Z.A. Saleem. Lead concentration in
soils along the
2. Richard H. Stanton, MS (1974), currently at Chevron Chemicals, MD
3. Dr. Shahid H. Ashrafi, Visiting Scientist (1974), currently Professor
of Oral Pathology, UIC
Dental School
4. Dr. Pupala Sudershan, postdoc (1976-79), currently at Abbotts Lab,
West Chicago
5. Dr. Gunda Reddy, postdoc (1974-77), currently at Defense Laboratory,
MD
6. Dr. Dennis F. Rio, postdoc, currently instructor at a community
college in IL.
7. Dr. Curtis Conroy, postdoc (1979)
8. Lela V. Jovanovich, PhD (1987), currently at Waste Management, Westmont
9. Lawrence T. Martin, MS (1984), currently at College of Dupage, Lombard
10. John Elgin, MS (1990), currently an MD (pathologist)
11. Hyder M. Khan, MS (1974), currently an MD-PhD (pediatrician)
12. Dr.Mohammed Feroz, postdoc (1976-79), currently Exec. VP, Quad
Pharmaceuticals,
Indianopolis
13. Dr. Syed Y. Qadri, postdoc (1997-1999), currently at Chicago City
Colleges
14. Sally A. Levin, MS (1991)
on the toxicity and metabolism of cyclodiene insecticides and their
photoisomers in houseflies. J. Econ. Entomol., 16:470-475
2.1971a E. Georgacakis and M.A.Q. Khan. Toxicity of the photoisomers
of cyclodiene
insecticides to freshwater animals. Nature, 233:120-121
3.1971b E. Georgacakis, S.R. Chandran and M.A.Q. Khan. Metabolism
toxicity relationship of the photoisomers of cyclodiene insecticides
in aquatic animals. Bull. Environ.
Contamin. Toxicology, 6:535-538
4.1972a M.A.Q. Khan. Biochemical Toxicology of Insecticides:
Book review. Bull.
Entomol. Soc. Amer., 17(4):89-90
5.1972b A.A. Khan, W. Bauer and M.A.Q. Khan. Crystal and molecular
structure of
photoaldrin. Acta Crystolog., B28:2060-2065
6.1973a M.A.Q. Khan, N. Maitra, D.J. Sutherland, J.D. Rosen and R.H.
Stanton.
Toxicity-metabolism relationship of the photoisomers of cyclodiene
insecticides. Arch. Environ. Contamin. Toxicol., 1(1):159-170
7.1973c M.A.Q. Khan. Fate of cyclodiene insecticides in the environment.
Proceed.
Entomol. Soc. Karachi., 2:25-35
8.1974a H.M. Khan and M.A.Q. Khan. Biological magnification of photodiedrin
by
food chain organisms. Arch. Environ. Contam. Toxicol., 2:289-301
9.1974b G. Reddy and M.A.Q. Khan. In vitro metabolism of 14C
photodieldrin by microsomal mixed-function oxidase of mouse,
rat and
housefly. J.Aqric. Food. Chem., 22:910-912
10.1974c M.A.Q. Khan, R.H. Stanton and G. Reddy. Detoxication
of foreign chemicals
by invertebrates. In: Survival in Toxic Environments (M.A.Q.
Khan and J.P.Bederka, Jr., eds.). Acad. Press. pl77-202
11.1974d M.A.Q. Khan, H.M. Khan and D.J. Sutherland. Photolysis of
insecticides and
its ecological and health significance. In: Survival in Toxic Environments
(M.A.Q. Khan and J.P. Bederka, Jr., eds.). Acad. Press. p333-356
12.1974g. M.A.Q. Khan and J.P. Bederka, Jr., eds.. Survival in
Toxic Environments
Acad. Press. 553pp
13.1975a G. Reddy and M.A.Q. Khan. Fate of 14C-photodiedrin under
various
environmental conditions. Bull. Environ. Contam. Toxicoi., 13:64-72
14.1975b M.A.Q. Khan, M.L. Gassman and S.H. Ashrafi. Detoxification
of pesticides by
biota. In: Environmental Dynamics of Pesticides (R. Haque and
V.H. Freed, eds.). Plenum Publications.
p289-330
15.1975f S. Neudorf and M.A.Q. Khan. Absorption and metabolism
of DDT, dieldrin
and photodieldrin by freshwater organisms. Bu11. Environ. Contam.
Toxicol., 13:443-452
16.1975g G. Reddy and M.A.Q. Khan. Metabolism, excretion and
tissue distribution of
14C-photodieldrin in male rabbits following single oral and intraperitoneal
administration. J. Aqr. Food Chem., 23:861-866
17.1975h H.M. Khan, S. Neudorf and M.A.Q. Khan. Absorption and
elimination of
photodieldrin by Daphnia and goldfish. Bull. Environ. Contam. Toxicol.,
13(6):582-587
18.1976a M.A.Q. Khan, M.L. Gassman and R. Haque. Biodegradation
of Pesticides.
Chem. Technol., 6:62-69
19.1977a M.A.Q. Khan, S.H. Ashrafi and S. Decker. Hepatic ultrastructure
of chlordene
fed pigeons. Archiv. Environ.
Contam. Toxico1., 5:385-402
20.1977b G. Reddy and M.A.Q. Khan. Metabolism of 14C-photodieldrin
in houseflies.
J. Agri. Food Chem., 25:25-28
21.1977c M.A.Q. Khan. Elimination of pesticides by aquatic animals.
In: Pesticides in
Aquatic Environments (M.A.Q. Khan, ed.). Plenum Press. pl07-126
22.1977d M.A.Q. Khan, F. Korte and J.F. Payne. Metabolism of pesticides
by aquatic
animals. In: Pesticides in Aquatic Environments (M.A.Q. Khan,
ed.). Plenum Press. p l07-126
23.1977e M.A.Q. Khan (ed.). Pesticides in Aquatic Environments
Plenum Press. 257 pp
24.1977f R. Moore E.. Toro, M. Stanton and M.A.Q. Khan. Absorption
and elimination
of 14C- and gamma-chlordane by freshwater alga, daphnid, and goldfish.
Arch. Environ. Contam. Toxicol., 6:411-420
25.19779 G. Reddy and M.A.Q. Khan. Metabolism of 14C-photoisodrin
in mice and
houseflies. Gener. Pharmacol., 8:285-289
26.1978a G. Reddy and M.A.Q. Khan. Unirany metabolites of 14C-photodieldrin
in
male rabbits. J. Agr. Food Chem., 26:292-294
27.1978b M.A.Q. Khan, M. Feroz and A.A. Podowski. Ecological and health
effects of
photolysis products of chlorinated hydrocarbons. Reprints of papers
presented at 176th National Meeting of American Chemical Society, Div.
of Environmental Chem., 18(2):347-349
28.1979a M.A.Q. Khan, M. Feroz and P. Sudershan. Metabolism of cyclodiene
insecticides in fish. In: Pesticide and Xenobiotic Metabolism
in Aquatic Organisms (M.A.Q. Khan, J.J. Lech and J.J. Menn, eds.). Amer.
Chem. Soc. p37-56
29.1979b M.A.Q. Khan, J.J. Lech and J.J. Menn (Eds.). Pesticide
and Xenobiotic
Metabolism in Aquatic Organisms. Amer. Chem. Soc. 406 pp
30.1979e M. Feroz and M.A.Q. Khan. Fate of 14C-photoheptachlor in rabbits.
J. Agr.
Food. Chem., 27:108-113
31.1979f M. Feroz and M.A.Q. Khan. Metabolism of 14C-cischlordane
in the American
cockroach, Periplaneta americana (L). J. Agr. Food Chem., 27:95-103
32.1979g M. Feroz and M.A.Q. Khan. Fate of cis-chlordane in goldfish
(Carassius
auratus). Bull. Environ. Contam. Toxicoi., 23:64-69
33.1979h M. Feroz and M.A.Q. Khan. Metabolism of 14C-heptachlor
in goldfish
(Carassius auratus). Arch. Environ. Contam. Toxicol., 8:519-531
34.1979i D.A. Ducat and M.A.Q. Khan. Absorption and elimination
of 14C-chlordane
and 14C-chlordane by goldfish (Carassius auratus). Arch. Environ. Contam.
Toxicol., 8:1409-1417
35.1979j A.A. Podowski, B.C. Banerjee, M. Feroz, M.A. Dudek, R.L. Willey
and
M.A.Q. Khan. Photolysis of hepLachlor and cis-chlordane and toxicity
of their
photoisomers to animals. Arch. Environ. Contam. Toxicol. 8:509-518
36.1979k M. Feroz and M.A.Q. Khan. Metabolism, tissue distribution,
and elimination
of 14C-chlordane in the tropical freshwater fish, Cichlasoma sp. J.
Agr. Food Chem., 27:190-195
37.1979m M. Feroz and M.A.Q. Khan. Biotransformation of photoheptachlor
in the rat.
I. Excretion, storage, and isolation of metabolites. Pestic.
Biochem. Physiol., 12:147-155
38.1979n P. Sudershan and M.A.Q. Khan. Metabolism of 14Cphotodieldrin
in bluegill.
Pestic. Biochem. Physiol., 12:272
39.1980a M.A.Q. Khan. Induction of drug metabolizing enzymes
by insecticides and
other xenobiotics. Pharmacol. Therap., 10:43-107
40.1980b M. Feroz and M.A.Q. Khan. Metabolic fate of photo-cis
chlordane in the rat.
1.Excretion, tissue distribution, and preliminary characterization
of metabolites.
J. Agr. Food Chem., 28:740-745
41.1980c P. Sudershan and M.A.Q. Khan. Uptake, elimination and
metabolic fate of
14C-chlordane in bluegill fish. J. Agric. Food Chem., 28:291-296
42.1980d M.A.Q. Khan, M. Feroz, A.A. Podowski, and L. Martin.
Ecological and health
effects of the photolysis products of chlorinated hydrocarbon pesticides.
In: Dynamics, Exposure, and Hazard Assessment of Toxic Chemicals in Environment
(R. Haque, ed.). Ann Arbor Science, Michigan. p393-416
43.1980e M. Feroz and M.A.Q. Khan. Biotransformation of photoheptachlor
in the rat.
11. Analysis, distribution and chemical characterization of metabolites.
Pestic. Biochem. Physiol., 13:294-302
44.1980f P.Sudershan and M.A.Q. Khan. Photodieldrin metabolism
in goldfish. Pestic.
Biochem. Physiol., 13:148-157
45.1980g M. Feroz, P. Sudershan and M.A.Q. Khan. Book Review:
The Use and
Significance of Pesticides in Environment. BioSci., 30(9):615
46.1980h M. Feroz, P. Sudershan, and M.A.Q. Khan. Book Review:
Pesticides:
Contemporary Role in Agriculture, Health and the Environment.
BioSci., 30(6):418
47.1980i P. Sudershan and M.A.Q. Khan. Metabolic transformation
of endrin in
bluegill. Pestic. Biochem. Physiol., 14:5-11
48.1980j M.A.Q. Khan, L.T. Martin, R.L. Willey, and M. Feroz. Biochemical
and
ultrastructural alteration of rat liver by photoheptachlor. Amer.
Chem. Soc., Div. of Environmental Chem., 22(2):423-425
49.1980k M.A.Q. Khan, P. Sudershan, M. Feroz, A.A. Podowski, and M.E.
Shackelford.
Comparative metabolism of hexachloro cyclopentadiene and cyclodienes
and their photoisomers in fish and mammals. Amer. Chem. Soc., Div.
of Environmental Chem., 22(2):494-497
50.1981a M.A.Q. Khan and R.H. Stanton (editors). Toxicoloay of
Halogenated
Hydrocarbons. Pergamon Press. 405 pp.
51.1981d M.A.Q. Khan, P. Sudershan, M. Feroz, and A.A. Podowski.
Comparative
metabolism of cyclodienes and their photoisomers in mammals and fish.
In:
Toxicolony of Halogenated hydrocarbons (M.A.Q. Khan and R.H. Stanton,
Eds.). Pergamon Press. p272-298
52.1981e M. Feroz, J. Kagan, S. Ramesh, and M.A.Q. Khan. Photoisomerization
of cis
chlordane. Identification of two isomers of photo-chlordane.
J. Agr. Food Chem., 29:272-276
53.1981f M.A.Q. Khan, R.L. Willey, L.Martin, and M. Feroz. Biochemical
and
ultrastructural changes in rat liver following photoheptachlor treatment.
In: Toxicology of Halogenated Hydrocarbons. (M.A .Q.Khan and R .H
. Stanton Eds.). Pergamon Press. pl21-132.
54.1981 P. Sudershan and M.A.Q. Khan. Biotransformation of Dieldrin
in Bluegil.
Pestic. Biochem. Physiol., 15:192-199.
55.1984a A.A .Podowski, M. Feroz, P. Mertens, and M.A.Q .Khan.
HPLC analysis of
organochlorines using uv and radioactive flow detectors. Bull.
Environ.Contam. Toxicol., 32:301-309.
56.1984b M.A.Q. Khan. Induction of drug metabolizing enzymes.
In: Differential
Toxicities of Insecticides and Aryl Hydrocarbons (F Matsumura, ed.).
International Encyclopedia of Pharmacology and Therapeutics., Sec: 113:126-220,
Pergamon Press.
57.1984c A.A. Podowski and M.A.Q. Khan.Fate of hexachlorocyclopentadiene
in water
and goldfish. Arch. Environ. Contam. Toxicol., 13:471-481.
58.1985 M.A.Q. Khan, P. Sudershan, and A.A. Podowski, Significance
of
photoalteration and bioalteration of chemicals. Amer. Chem. Soc.,
Div. of Environmental Chem., 27(2):430-433.
59.1987 L.Jovanovich, S.A. Levin and M.A.Q. Khan. Significance
of mirex
caused hypoglycemia and hyperlipidemia in rats. J. Biochem. Toxicol.,
2(4):203-214.
60.1990a M.A.Q. Khan. Biochemical effects of pesticides on mammals.
In: Chemistry
of Plant Protection (G.Haug and H.Hoffmann, Eds.), 6:109-171. Springer
Verlag, Berlin.
61.l990b M.Feroz, A.A. Podowski, and M.A.Q .Khan. Oxidative dehydrochlorination
of
heptachlor by Daphnia magna. Pestic. Biochem. Physiol., 36:101-105.
62.1990c J. Elgin, L. Jovanovich, S .Vahed, and M.A.Q. Khan. Alteration
of hepatic
lipids by mirex in rats. Pestic. Biochem. Physiol. 38:273-285.
63.1991a A.A. Podowski, S.L. Sclove, A. Pipipowicz, and M.A.Q Khan.
Biotransformation and disposition of hexachlorocyclopentadiene in fish.
Arch. Environ. Contam. Toxicol.,
64.1992a D.A. Ducat and M.A.Q. Khan. Fate ofthe flame retardant
MC-984 in
goldfish. Bull. Environ. Contamin. Toxicol. 49: 569-575.
65.1992b. J.K. Jakalaski and M.A.Q. Khan. Photolysis of aldrin
and dieldrin in a
phytoplankton. Arch. Environ. Contamin. Toxicol. 24:75-79.
2. Lawrence T. Martin, MS (1984), currently at College of Dupage, Lombard
3. Dr. Ruth L. Willey, retired-Assoc. Professor in Biol. Sciences,
UIC
4. Dr. Shahid H. Ashrafi, visiting scientist (1974), currently Professor
of Pathology, UIC Dental School
5. J. Elgin, MS (1990), currently an MD (Pathologist)
6. S.A.Levin, MS (1991)
photoalteration and bioalteration of chemicals. Amer. Chem. Soc.,
Div. of Environmental Chem., 27(2):430-433.
2. 1987 L.Jovanovich, S.A. Levin and M.A.Q. Khan. Significance
of mirex
caused hypoglycemia and hyperlipidemia in rats. J. Biochem. Toxicol.,
2(4):203-214.
3. 1990a M.A.Q. Khan. Biochemical effects of pesticides on mammals.
In: Chemistry
of Plant Protection (G.Haug and H.Hoffmann, Eds.), 6:109-171. Springer
Verlag, Berlin.
4. l990b M.Feroz, A.A. Podowski, and M.A.Q .Khan. Oxidative dehydrochlorination
of
heptachlor by Daphnia magna. Pestic. Biochem. Physiol., 36:101-105.
5. 1990c J. Elgin, L. Jovanovich, S .Vahed, and M.A.Q. Khan. Alteration
of hepatic
lipids by mirex in rats. Pestic. Biochem. Physiol. 38:273-285.
2. May E. Shackelford, MS (1978), PhD (1986), currently at FDA
3. Mike Doherty, MS (1978)
4. Joe Grossman, MS (1975)
5. Dr. Syed Y. Qadri, postdoc (1996-98), currently at Chicago City
Colleges
microsomal mixed-function oxidase in the freshwater crayfish, Cambarus.
Life Sci., 11(2):405-415
2. 1972d S.R. Chandran and M.A.Q. Khan. Mixed-function oxidase in the
mid
gut of the corn earworm, Heliothis zea (Boddie). J. Econ. Entomol.,
65:1510-1512
3. 1972e M.A.Q. Khan, A. Kamal, R.J. Wolin and J. Runnels. In
vivo and In vitro
epoxidation of aldrin by aquatic food chain organisms. Bull.
Environ. Contamin. Toxicol., 8(4):219-228
4. 1972g M.A.Q. Khan and F. Matsumura. Induction of the mixed-function
oxidase by
DDT and dieldrin in the German and American cockroach. Pest.
Biochem. Physiol., 2(2):223-243
5. 1973a M.A.Q. Khan, N. Maitra, D.J. Sutherland, J.D. Rosen and R.H.
Stanton.
Toxicity-metabolism relationship of the photoisomers of cyclodiene
insecticides. Arch. Environ. Contamin. Toxicol., 1(1):159-170
6. 1973b R.H. Stanton and M.A.Q. Khan. Mixed-function oxidase activity
toward
cyclodiene insecticides in bass and bluegill sunfish.
Pest. Biochem. Physiol., 3:351-357
7. 1973c M.A.Q. Khan, R.l. Morimoto, J.P. Bederka and J.M. Runnels.
Genetic control
of the housefly microsomal mixed-function oxidase by Oxidase 1 and
Oxidase 5 genes. Biochem. Gen., 10:243-252
8. 1974b G. Reddy and M.A.Q. Khan. In vitro metabolism of 14C
photodieldrin by microsomal mixed
function oxidase of mouse, rat and housefly.
J. Aqr. Food. Chem., 22:910-912
9. 1974c M.A.Q. Khan, R.H. Stanton and G. Reddy. Detoxication
of foreign chemicals
by invertebrates. In: Survival in Toxic Environments (M.A.Q.
Khan and J.P.Bederka, Jr., eds.). Acad. Press. pl77-202
10. 1975c J.M. Runnels and M.A.Q. Khan. Characterization of the
mixed-function
oxidase of pigeon. General Pharmacol., 6(2):97-104
11. 1975d M. Garretto and M.A.Q. Khan. Hydroxylation and epoxidation
of chlordene
by the mixed-function oxidase of the tropical and cold freshwater fishes.
Gen.
Pharmacol., 2(3):91-96
12. 1975e R.H. Stanton and M.A.Q. Khan. Components of the mixed
function oxidase of
freshwater fishes. Gen. P
13. 1976b R.H. Stanton and M.A.Q. Khan. Isolation and purification
of cytochrome
P-450 from uninduced mouse liver. Biochem. Biophys. Res. Commun.,
72:128-139
14. 1979c B. Phillips and M.A.Q. Khan. Hepatic microsomal epoxide
hydratase of
bluegill. Biochem. Biophys. Res. Commun. 89:333-337
15. 1979d M.O. James, M.A.Q. Khan and J.R. Bend. Hepatic microsomal
mixed
function oxidase activities in several marine species common to coastal
Florida. Compar. Biochem. Physiol., 62:155-164
16. 19791 J.C. Grossman and M.A.Q. Khan. Metabolism of naphtha
lene by the hepatic
mixed-function oxidase of the pigeon. Comp. Biochem. PhysioI.,
63(c):251-260
17. 1973b R.H. Stanton and M.A.Q. Khan. Mixed-function oxidase activity
toward
cyclodiene insecticides in bass and bluegill sunfish.
Pest. Biochem. Physiol., 3:351-357
18. 1973c M.A.Q. Khan, R.l. Morimoto, J.P. Bederka and J.M. Runnels.
Genetic control
of the housefly microsomal mixed-function oxidase by Oxidase 1 and
Oxidase 5 genes. Biochem. Gen., 10:243-252
19. 1980a M.A.Q. Khan. Induction of drug metabolizing enzymes
by insecticides and
other xenobiotics. Pharmacol. Therap., 10:43-107
20. 1981b M.J. Doherty and M.A.Q. Khan. Hepatic mixed-function
oxidase of the frog,
Xenopus laevi. Compar. Biochem. Physiol., 68:221-228
21. 1981c M.E. Shackelford and M.A.Q. Khan. Hepatic mixed-function
oxidase of the
mallard duck (Anas platyrhynchos). Compar. Biochem. Physiol., 70:77-84
72.
22. 1984b M.A.Q. Khan. Induction of drug metabolizing enzymes.
In: Differential
Toxicities of Insecticides and Aryl Hydrocarbons (F Matsumura, ed.).
International Encyclopedia of Pharmacology and Therapeutics., Sec: 113:126-220,
Pergamon Press.
23. 1995b. M.A.Q. Khan, S.N.H. Naqvi, and S.M.A. Ghais. Genetics
of detoxication
enzymes in insects and other animals.
In: Biotechnology for Environment and
Agriculture (N.Ahmed, ed.). Center for
Molecular Genetics, University of
Karachi, Karachi. p 1-31.
24. 1998a. M.A.Q. Khan, L.V. Jovanovich, L.T. Martin, S.Y.Qadri, and
A.A. Podowski. Effects of photoisomers
of cyclodiene insecticides on liver and
microsomal cytochrome P-450 in rats.
Arch. Toxicol. 7 2:74-83.
25. 1998b. M.A.Q. Khan, S.Y. Qadri, S. Tomar, D.Fish, L. Gururajan,
and M.S. Poria
Induction of hepatic cytochrome P450
by phenobarbital. in semi-aquatic frog Rana
pipiens . Biochem. Biophys. Res. Commun.
244:737-745
2. Dr. D.G.V.P.Rao, visiting scientist
3. several undergraduate students contributed to this project. Most
of these are in medical and dental schools.
Chicago's Eisenhower and Terminal Expressways. Arch. Environ.
Contamin. Toxicol., 1:209-223
2. 1974c W.F. Coello, Z.A. Saleem and M.A.Q. Khan. Ecological and health
effects of
lead in auto-exhaust. In: Survival in Toxic Environments (M.A.Q. Khan
and J.P.Bederka, Jr., eds.). Acad. Press. p499-514
3. 1996b. W.F. Coello and M.A.Q. Khan. Protection against heavy
metal toxicity by
mucus and scales in fish. Arch. Environ. Contamin.Toxicol.
30:319-326
4. 1997. D.G.V.P. Rao and M.A.Q. Khan. Zebra mussels: Potentiation
of toxicity of
copper by high temperature. In: Proceed. Annual Meeting of Water
& Environment Feder. 144-149.
5. 1998c. W.F. Coello and M.A.Q. Khan. Effects of keratin on heavy
metal chelationand
toxicity to aquatic organisms. In: Symposium on Toxicology &
RiskAssessment.Seventh Volume (E.E.Little, A.J.DeLony, & B.M. Greenberg,
Eds.) ASTM STP 1333, Amer. Soc. Testing & Materials. 233-239.
6. 2000a. D.G.V.P. Rao, R.B. Angoluan, G. Myron, S.M. Balu, and M.A.Q.
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Temperature synergism of heavy metal toxicity in aquatic invertebrates.
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