Post-doctoral and PhD student positions available>
We're interested in hearing from you, if you would like to join our group


 




Our publications:

  • Miller, R.R., and Okkema, P.G. (2011). The Caenorhabditis elegans T-Box Factor MLS-1 Requires Groucho Co-Repressor Interaction for Uterine Muscle Specification. PLoS Genet 7, e1002210.

  • Clary, L.M., and Okkema, P.G. (2010). The EGR family gene egrh-1 functions non-autonomously in the control of oocyte meiotic maturation and ovulation in C. elegans. Development 137, 3129-3137.

  • Ray, P., Schnabel, R. and Okkema, P. G. (2008). Behavioral and synaptic defects in C. elegans lacking the NK-2 homeobox gene ceh-28. Dev Neurobiol 68, 421-33.

  • Crum, T. L. and Okkema, P. G. (2007). SUMOylation-dependent function of a T-box transcriptional repressor in Caenorhabditis elegans. Biochem Soc Trans 35, 1424-6.

  • Franks, D. M., Izumikawa, T., Kitagawa, H., Sugahara, K. and Okkema, P. G. (2006). C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans. Dev Biol 296, 409-20.

  • Roy Chowdhuri, S., Crum, T., Woollard, A., Aslam, S. and Okkema, P. G. (2006). The T-box factor TBX-2 and the SUMO conjugating enzyme UBC-9 are required for ABa-derived pharyngeal muscle in C. elegans. Dev Biol 295, 664-77.

  • Okkema, P. G. and Krause, M. (2005). Transcriptional regulation. WormBook, 1-40.

  • Beaster-Jones, L. and Okkema, P. G. (2004). DNA binding and in vivo function of C. elegans PEB-1 require a conserved FLYWCH motif. J Mol Biol 339, 695-706.

  • Fernandez, A. P., Gibbons, J. and Okkema, P. G. (2004). C. elegans peb-1 mutants exhibit pleiotropic defects in molting, feeding, and morphology. Dev Biol 276, 352-66.

  • Vilimas, T., Abraham, A. and Okkema, P. G. (2004). An early pharyngeal muscle enhancer from the Caenorhabditis elegans ceh-22 gene is targeted by the Forkhead factor PHA-4. Dev Biol 266, 388-98.

  • Kalb, J. M., Beaster-Jones, L., Fernandez, A. P., Okkema, P. G., Goszczynski, B. and McGhee, J. D. (2002). Interference Between the PHA-4 and PEB-1 Transcription Factors in Formation of the Caenorhabditis elegans Pharynx. J Mol Biol 320, 697-704.

  • Kuchenthal, C. A., Chen, W. and Okkema, P. G. (2001). Multiple enhancers contribute to expression of the NK-2 homeobox gene ceh-22 in C. elegans pharyngeal muscle. Genesis 31, 156-66.

  • Thatcher, J. D., Fernandez, A. P., Beaster-Jones, L., Haun, C. and Okkema, P. G. (2001). The Caenorhabditis elegans peb-1 gene encodes a novel DNA-binding protein involved in morphogenesis of the pharynx, vulva, and hindgut. Dev Biol 229, 480-93.

  • Thatcher, J. D., Haun, C. and Okkema, P. G. (1999). The DAF-3 Smad binds DNA and represses gene expression in the Caenorhabditis elegans pharynx. Development 126, 97-107.

  • Haun, C., Alexander, J., Stainier, D. Y. and Okkema, P. G. (1998). Rescue of Caenorhabditis elegans pharyngeal development by a vertebrate heart specification gene. Proceedings of the National Academy of Sciences of the United States of America 95, 5072-5.

  • Kalb, J. M., Lau, K. K., Goszczynski, B., Fukushige, T., Moons, D., Okkema, P. G. and McGhee, J. D. (1998). pha-4 is Ce-fkh-1, a fork head/HNF-3alpha,beta,gamma homolog that functions in organogenesis of the C. elegans pharynx. Development 125, 2171-80.

  • Okkema, P. G., Ha, E., Haun, C., Chen, W. and Fire, A. (1997). The Caenorhabditis elegans NK-2 homeobox gene ceh-22 activates pharyngeal muscle gene expression in combination with pha-1 and is required for normal pharyngeal development. Development 124, 3965-73.

  • Okkema, P. G. and Fire, A. (1994). The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle. Development 120, 2175-86.

  • Okkema, P. G., Harrison, S. W., Plunger, V., Aryana, A. and Fire, A. (1993). Sequence requirements for myosin gene expression and regulation in Caenorhabditis elegans. Genetics 135, 385-404.